Radiologic features included short metacarpals with rounded proximal heads, agenesis of the radial ray, epiphyseal coning, and an unusual supernumerary ossicle opposed to the distal phalanx of the left thumb. Two individuals had nail dysplasia, and 1 had cleft palate. The feet were more severely affected than the hands. The phenotype was highly variable, ranging from the classic ectrodactyly deformity to partial absence of the thumb and agenesis of the distal tip of the index finger. (2004) described a large autosomal dominant pedigree segregating split-hand/foot linked to chromosome 10q24 (SHFM3).
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